Haplotype Reconstruction and Estimation of Haplotype Frequencies from Nuclear Families with Only One Parent Available
نویسندگان
چکیده
منابع مشابه
Haplotype reconstruction and estimation of haplotype frequencies from nuclear families with only one parent available.
Recent literature has suggested that haplotype inference through close relatives, especially from nuclear families can be an alternative strategy in determining the linkage phase. In this paper, haplotype reconstruction and estimation of haplotype frequencies via expectation maximization (EM) algorithm including nuclear families with only one parent available is proposed. Parent and his (her) c...
متن کاملHaplotype reconstruction and estimation of haplotype frequencies from nuclear families with one parent available and varying numbers of children using the exact likelihood.
this family is divided into two independent parent-child pairs {(H i , H j ), (H i , H k )} and {(H i , H j ), (H i , H i )} as described above, the number of occurences of H i , H j , and H k is 3, 2, 1. Therefore, the approximation used in Ding et al. [1] for multiple children families will bias the frequency estimates of some haplotypes. Despite this approximation was empirically shown to be...
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Determining linkage phase from population samples with statistical methods is accurate only within regions of high linkage disequilibrium (LD). Yet, affected individuals in a genetic mapping study, including those involving cases and controls, may share sequences identical-by-descent stretching on the order of 10s to 100s of kilobases, quite possibly over regions of low LD in the population. At...
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A commonly used tool in disease association studies is the search for discrepancies between the haplotype distribution in the case and control populations. In order to find this discrepancy, the haplotypes frequency in each of the populations is estimated from the genotypes. We present a new method HAPLOFREQ to estimate haplotype frequencies over a short genomic region given the genotypes or ha...
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ژورنال
عنوان ژورنال: Human Heredity
سال: 2006
ISSN: 0001-5652,1423-0062
DOI: 10.1159/000095598